Erratum: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
نویسندگان
چکیده
This Article contains errors in Figs 4,6 and 7 that were introduced during the production process. In Fig. 4j, the lane labels on the blot should read in order ‘InputNo Ab-IgG-Flag’. In Fig. 6i, the x axis label ‘WT PP2A’ of the two graphs should read ‘DN PP2A’. Finally, in Fig. 7a, the maximal cell number reported in the table for the injection of CCS and HT29 should read ‘1 105’ and not ‘1 104’. The correct versions of each figure appear below as Figs 1,2 and 3, respectively. DOI: 10.1038/ncomms14027 OPEN
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Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
Targeting tumour-initiating cells (TICs) would lead to new therapies to cure cancer. We previously demonstrated that TICs have the capacity to survive under suspension conditions, while other cells undergo anoikis. Here we show that TICs exhibit increased phosphorylation levels of S727STAT3 because of PP2A inactivation. Collagen 17 gene expression is upregulated in a STAT3-dependent manner, whi...
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